Chelsea will definitely be without the services of Hakim Ziyech, who suffered a shoulder injury during the UEFA Super Cup with Villarreal on Wednesday night.
Jorginho, Mason Mount, Andreas Christensen and Cesar Azpilicueta all appeared off the bench against the Yellow Submarine, and it would not be a surprise to see all four players come into the XI this weekend.
Marcos Alonso could ultimately get the nod as the left-sided wing-back due to Ben Chilwell's lack of action since the end of last season, while Reece James might also start on the bench, with Callum Hudson-Odoi operating on the right.
Further forward, Timo Werner and Mount could be joined by Kai Havertz, but Lukaku will not be involved, as the striker is in quarantine following his move from Inter Milan.
As for Palace, new signing Olise is unlikely to be available due to a back problem, while Eberechi Eze is definitely out, as the midfielder works his way back from a serious Achilles injury.
Nathan Ferguson is also out with an Achilles rupture, while Vieira will need to assess the fitness of a number of players before naming his starting XI this weekend.
Wilfried Zaha is a certainty to start in the final third of the field, while there could be a debut for Guehi against his former club, but Gallagher is ineligible to play against his parent side, having arrived on loan from Tuchel's side this summer.
Chelsea possible starting lineup:
Mendy; Azpilicueta, Christensen, Rudiger; Hudson-Odoi, Kante, Jorginho, Alonso; Mount, Werner, Havertz