South Africa and Ghana will be playing against each other for the 14th time since their first-ever meeting in November 1994 when Bafana won 2-1 in a Four Nations Tournament at Loftus Versfeld.
Ghana have recorded victory on three occasions and lost mytwice including their last Group C match away in Sudan.
While South Africa have been under Ntseki in all their matches in this pool, the Black Stars began this qualifying bid under Kwesi Appiah who guided them to victories over Bafana and Sao Tome.
Charles Kwabla Akonnor then took over and led them to a 2-0 win over Sudan, before they were edged 1-0 by the same opponents to drop points in this group for the first time.